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A cost-effective combined advanced therapy to treat knee osteoarthritis

National Institute of Health and Medical Research

Founded in 1964, INSERM is a public scientific and technological institute which operates under the joint authority of the French Ministries of Health and Research. The institute is dedicated to biomedical research and human health, and is involved in the entire range of activities from the laboratory to the patient’s bedside. It also partners with the most prestigious research institutions in the world that are committed to scientific challenges and progress in these fields.
In SINPAIN, the Laboratory for the Bioengineering of Tissues (BioTis U1026) is included for INSERM. It is a so-called Unité Mixte de Recherche (UMR) that combines individuals from the French National Institute of Health and Medical Research (INSERM) and the Université de Bordeaux. The University of Bordeaux was founded almost six centuries ago. It welcomes 54 000 students and 6000 staff members. The University of Bordeaux offers 250 Master programs, 150 Bachelor programs and 55 national diplomas in health. It includes departments in Science and Technolog, Law and Political Science, Economics, Management, Life and Health Sciences, Social and Human Sciences.
The BioTis group involved in SINPAIN has been a national leader in the field of bone and vascular tissue engineering for over 30 years. The research at BioTis spans from the fundamental aspects of cell-cell and cell-matrix interactions, all the way to the development of translational models and their clinical applications in vascular, orthopedic, oral and maxillofacial surgery.

Role within SINPAIN

In SINPAIN, BioTis will analyse patient samples of different grades of OA in terms of inflammation, presence of vascular structures and nerve fibers. They will also responsible for the production of sensory neurons from human induced pluripotent stem cells and for the co-cultures of these cells with chondrocytes and immune cells, as well as their phenotype analysis. They will also carry out proteomic analysis of the tissue samples and cell cultures.

Main contacts

Photo of Olivier Chassande
Olivier Chassande

Team Leader

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Joelle Amende

Deputy Team Leader