cmRNAbone project releases video on its accomplishments in RNA therapy

Due to demographic change, bone degenerating diseases like osteoporosis and osteoarthritis are steadily increasing. The need for novel therapies is therefore tremendous.

SINPAIN has been active since its start to collaborate with other projects in the field to exchange about different approaches in health-related biomaterial research. One of these projects was cmRNAbone that has come to an end in June 2024.

While SINPAIN seeks to advance RNA-based therapies for the treatment of osteoarthritis in the knee, focusing on the use of small interference RNA (siRNA), the EU-funded project cmRNAbone focused on improving the lives of people with large traumatic injuries or bone degenerating diseases such as osteoporosis by using a unique combination of genetic research, advanced nano- and biotechnology and 3D-printing. The consortium has aimed to develop chemically modified RNA encoding specific proteins targeting neurogenesis, vasculogenesis and osteogenesis – three major processes influencing the healing progression. The produced RNA sets were combined with non-viral vectors for the RNA delivery to be embedded in a biomaterial ink formulation. The use of a specifically designed 3D-printer for the implant helps to demonstrate the bone regenerative capabilities in practice.

cmRNAbone is showcasing the project's main accomplishments in a brand-new video. The video and interviews were filmed at AO Research Foundation who is also a strong partner in SINPAIN.

Watch the video here.