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A cost-effective combined advanced therapy to treat knee osteoarthritis

Cluster workshop co-organised by SINPAIN and cmRNAbone

The SINPAIN and cmRNAbone projects have teamed up to host a cluster workshop on 8 September 2023. The workshop will focus on discussing the latest advancements in osteoarthritis treatment and bone regeneration. It will be held on the sidelines of the ESB 2023 conference, and will be hosted by AO Research Institute Davos (ARI) which is a partner in both projects and also organiser of ESB 2023.

The cmRNAbone project has developed a unique approach that combines genetic research, advanced nano- and biotechnology, and 3D-printing. By utilising recent scientific discoveries related to RNA therapeutic agents, the consortium aims to develop chemically modified RNA that encodes specific proteins targeting neurogenesis, vasculogenesis, and osteogenesis. These three major processes play a crucial role in the healing progression. The produced RNA sets will be combined with non-viral vectors for delivery and embedded in a biomaterial ink formulation. A specially designed 3D-printer will be used to create the implant, demonstrating the bone regenerative capabilities of this innovative approach in practice.

ESB2023 is one of the premier biomaterials events of the year, attracting excellent and highly experienced scientists from other EU-funded projects in the field. As such, projects collaborating with SINPAIN and cmRNAbone have been invited to participate in this clustering event. We anticipate around 15-20 participants from various institutions, openly sharing their experiences in addressing the need for new treatments for osteoarthritis – a disease that remains one of the leading causes of physical disability, with ever-increasing numbers. A short recap of this event will be published in September 2023.